Anti-IKK beta Ser476 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-5442R-A750
BOSSBS-5442R-A750EA 921 EUR
BOSSBS-5442R-A750
Anti-IKK beta Ser476 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.

Type: Primary
Antigen: IKK beta Ser476
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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