Anti-MAP2K2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Lieferant: Bioss
BS-5498R-A555
BOSSBS-5498R-A555EA 1350 EUR
BOSSBS-5498R-A555
Anti-MAP2K2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Antikörper
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: MAP2K2
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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