Anti-TRP12 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Lieferant: Bioss
BS-6425R-A350
BOSSBS-6425R-A350EA 915 EUR
BOSSBS-6425R-A350
Anti-TRP12 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Antikörper
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: TRP12
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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