Anti-MRGPRX1/3/4 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Lieferant: Bioss
BS-6606R-A647
BOSSBS-6606R-A647EA 893 EUR
BOSSBS-6606R-A647
Anti-MRGPRX1/3/4 Rabbit Polyclonal Antibody (Alexa Fluor® 647)
Antikörper
There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: MRGPRX1/3/4
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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