Anti-SHOC2 Rabbit Polyclonal Antibody (Cy5.5®)

Lieferant: Bioss
BS-7934R-CY5.5
BOSSBS-7934R-CY5.5EA 893 EUR
BOSSBS-7934R-CY5.5
Anti-SHOC2 Rabbit Polyclonal Antibody (Cy5.5®)
Antikörper
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: SHOC2
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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