Anti-ANKRD11 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Lieferant: Bioss
BS-7961R-A750
BOSSBS-7961R-A750EA 893 EUR
BOSSBS-7961R-A750
Anti-ANKRD11 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antikörper
Ankyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate. It contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD(consisting of 2224 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sised C-terminal regulatory domain. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops. It has been studied using multiple sequence alignment to determine which conserved amino acid residues are critical for folding and stability. Ankyrin-repeat proteins have been associated with a number of human diseases; most notably, the cell cycle inhibitor p16 is associated with cancer and the Notch protein is a key component of cell signaling pathways whose intracellular repeat domain is disrupted in mutations that give rise to the neurological disorder known as CADASIL.

Type: Primary
Antigen: ANKRD11
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 731-820/3663
Host: Rabbit
Isotype: IgG
Reactivity: Human
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