Anti-P53 FL-393 Rabbit Polyclonal Antibody (ALEXA FLUOR® 750)

Lieferant: Bioss
BS-8687R-A750
BOSSBS-8687R-A750EA 890 EUR
BOSSBS-8687R-A750
Anti-P53 FL-393 Rabbit Polyclonal Antibody (ALEXA FLUOR® 750)
Antikörper
P53, a DNA-binding, oligomerisation domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localises to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

Type: Primary
Antigen: p53 FL-393
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 1-393/393
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat
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