Ratjadone A (synthetisch) ≥95%

Lieferant: ENZO LIFE SCIENCES

ALX270346C002
ENZOALX270346C002EA 316 EUR
ENZOALX270346C002
Ratjadone A (synthetisch) ≥95%
Ratjadone A

  • Solution in methanol


Represents a class of natural compounds, which inhibit proliferation in eukaryotes by blocking nuclear export. As potent as leptomycin B (Prod. No. ALX-380-100) and specific for G1/S checkpoint. Cytotoxic secondary metabolite (IC50=50pg/ml in mouse cell line L929) that arrests tumor cells in the G1 phase at remarkably low concentrations (50pg/ml in HeLa cell line KB3.1). Inhibits the binding between the nuclear export signal (NES) of proteins and the chromosome maintenance region protein (CRM1). Anticancer compound. Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds.


Synthetic.

Formel: C₂₈H₄₀O₅
Molecular Weight: 456,6 g/mol
CAS-Nummer: 163564-92-9

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