SU 9516 ≥95% (durch HPLC)

Lieferant: ENZO LIFE SCIENCES

Synonyme: SU9516, (Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one, 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one

ALX270400M005
ENZOALX270400M005EA 165 EUR
ENZOALX270400M005
SU 9516 ≥95% (durch HPLC)
SU 9516

Cell permeable, potent, selective and ATP-competitive inhibitor of CDK2/cyclin A (IC50=22nM), CDK1/cyclin B (IC50=40nM) and CDK4/cyclin D1 (IC50=200nM). Has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10µM). Displays anti-proliferative and pro-apoptotic properties in tumor cells. Inhibits proliferation of growth factor-stimulated colon carcinoma cells by binding to CDK2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.


  • CDK/cyclin inhibitor


Yellow to orange solid.


Soluble in DMSO (10mg/ml).

Formel: C₁₃H₁₁N₃O₂
Molecular Weight: 241,3 g/mol
Lagertemperatur: Kühlschrank
MDL: MFCD17010284
CAS-Nummer: 377090-84-1

Bestellen

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Mehr About VWR