SU 9516 ≥95% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
SU9516, (Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one, 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
Cell permeable, potent, selective and ATP-competitive inhibitor of CDK2/cyclin A (IC50=22nM), CDK1/cyclin B (IC50=40nM) and CDK4/cyclin D1 (IC50=200nM). Has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10µM). Displays anti-proliferative and pro-apoptotic properties in tumor cells. Inhibits proliferation of growth factor-stimulated colon carcinoma cells by binding to CDK2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.
- CDK/cyclin inhibitor
Yellow to orange solid.
Soluble in DMSO (10mg/ml).
Formel:
C₁₃H₁₁N₃O₂ Molecular Weight: 241,3 g/mol Lagertemperatur: Kühlschrank |
MDL:
MFCD17010284 CAS-Nummer: 377090-84-1 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...