Smoothened agonist ≥95%
Lieferant: ENZO LIFE SCIENCES
Synonyme:
3-Chloro-N-(trans-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide, 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(4-pyridinyl)benzyl]-1-benzothiophene-2-carboxamide, SAG
Smoothened ligand
A potent cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50= ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine (BML-GR334) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
Formel:
C₂₈H₂₈ClN₃OS Molecular Weight: 490,062 g/mol |
MDL:
MFCD22581513 CAS-Nummer: 912545-86-9 |
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