AMI-1 ≥98% (durch 1H-NMR, HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
AMI 1, Sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulphonate), 7,7'-(Carbonyldiimino)bis[4-hydroxy2-naphthalenesulphonicacid]disodiumsalt, 7,7′-Carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid) sodium salt, AMI-1 sodium salt
PRMT inhibitor
Potent, cell permeable and specific inhibitor of protein arginine N-methyltransferases (PRMTs) (IC50=8.8µM for human PRMT1 and 3.0µM for yeast Hmt1p). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Exhibits only minimal effects on lysine N-methyltransferases. Suppresses the transcriptional coactivator activity of PRMT1 and PRMT4. Inhibitor of HIV-1 RT polymerase (IC50=5.0µM).
Formel:
C₂₁H₁₄N₂Na₂O₉S₂ |
MDL:
MFCD00068249 CAS-Nummer: 20324-87-2 | 134-47-4 (free base) |
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