CDK1/2 Inhibitor III ≥95% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
5-Amino-3-((4-(aminosulphonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC50=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3β (IC50=32nM and 140nM).
White to off-white solid.
Soluble in DMSO (10mg/ml), tetrahydrofuran or acetone.
Formel:
C₁₅H₁₃F₂N₇O₂S₂ Molecular Weight: 425,4 g/mol Lagertemperatur: Gefrierschrank |
CAS-Nummer:
443798-55-8 |
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