Sauchinone
Lieferant: ENZO LIFE SCIENCES
Synonyme:
1′-Epimer dihydrocarpanone, (5aR,5a1R,7R,8S,8aR,14aS)-7,8-Dimethyl-5a,5a1,6,7,8,8a-hexahydro-5H-benzo[kl]bis([1,3]dioxolo)[4,5-b:4',5'-g]xanthen-5-one
Cytoprotective and antioxidant
Diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. Inhibitor of LPS-inducible iNOS (NOS II), TNF-alpha and COX-2 expression in macrophages through suppression of IkappaBalpha phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Suppressor of NF-kappaB by inhibiting transactivation activity of the RelA subunit. Inhibits staurosporine (Prod. No. ALX-380-014)-induced apoptosis. Inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.
Isolated from Saururus chinensis.
Formel:
C₂₀H₂₀O₆ Molecular Weight: 356,4 g/mol |
MDL:
MFCD08702698 CAS-Nummer: 177931-17-8 |
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