Rocaglamide ≥98% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
(1R,2R,3S,3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide
NF-kappaB inhibitor
Immunosuppressant. Potent inhibitor of NF-kappaB activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production (IFN-gamma, TNF-alpha, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-kappaB and AP-1 activities. In contrast to the immunosuppressant cyclosporin A (Prod. No. BML-A195), rocaglamide does not inhibit calcineurin phosphatase activity. Induces apoptosis.
Isolated from Aglaia sp.
Formel:
C₂₉H₃₁NO₇ Molecular Weight: 505.56 g/mol |
MDL:
MFCD08702699 CAS-Nummer: 84573-16-0 |
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