Leptomycin B 0,2 mg/ml ≥98% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-Ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
A potent and specific nuclear export inhibitor. In addition to antifungal and antibacterial activities, blocks the cell cycle and is a potent anti-tumor agent.
- Liquid
Leptomycin B alkylates and inhibits CRM1/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). At low nM concentrations, blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB and it stabilizes the expression of p53. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, Iκb, MPF and PKA. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.
Isolated from Streptomyces sp.
Liquid. In 100% ethanol.
Soluble in methanol or 100% ethanol, Insoluble in water, Unstable in DMSO
Formel:
C₃₃H₄₈O₆ Molecular Weight: 540,73 g/mol Lagertemperatur: Gefrierschrank |
MDL:
MFCD06795848 CAS-Nummer: 87081-35-4 |
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