Piericidin A (aus Streptomyces sp. MST-AS5364) ≥95% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
2-((2E,5E,7E,9R,10R,11E)-10-Hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl)-5,6-dimethoxy-3-methylpyridin-4-ol, SN 198E, Piericidin A ethanol solution, IT 143D, Shaoguanmycin B, Piericidin A1, MT 1882-I
Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.
- NADH-ubiquinone oxidoreductase inhibitor
Pale yellow oil.
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. Poorly soluble in water.
Formel:
C₂₅H₃₇NO₄ Molecular Weight: 415,6 g/mol Lagertemperatur: Gefrierschrank |
MDL:
MFCD01677956 CAS-Nummer: 2738-64-9 |
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