Necrox-2™
Lieferant: ENZO LIFE SCIENCES
Synonyme:
[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulphonyl-piperidin-4-yl)-amine
Necrosis inhibitor
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1µM NecroX™-2 prevented ~50% cell death in H9C2 cells exposed to 400µM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.
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