Necrox-5™ hydrochloride

Lieferant: ENZO LIFE SCIENCES

ALX430247M001
ENZOALX430247M001EA 178 EUR
ENZOALX430247M001
Necrox-5™ hydrochloride
Necrox-5™ hydrochloride

Necrosis inhibitor


Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.

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