Tranilast ≥95% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid, N-(3,4-Dimethoxycinnamoyl)anthranilic Acid
Anti-inflammatory and anti-angiogenic
Anti-inflammatory and anti-angiogenic agent. Inhibits VEGF-induced angiogenesis in vivo . Inhibits proliferation and tube formation of human endothelial cells in vitro. Also inhibits smooth muscle cell proliferation and prevents post-angiplasty retsenosis.Synthetic compound with structural similarity to the tryptophan (Trp) catabolites kynurenines. Tranilast ameliorates the disease severity in animal models of multiple sclerosis, in part, by inducing T cell tolerance. Trp degradation is an important mechanism in the maintenance of T cell tolerance in a variety of disease models and is mediated by the rate limiting enzyme indoleamine 2,3-dioxygenase (IDO).
Formel:
C₁₈H₁₇NO₅ Molecular Weight: 327,34 g/mol |
MDL:
MFCD00864787 CAS-Nummer: 53902-12-8 |
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