Ascomycin (aus Streptomyces species) ≥90% (durch HPLC, TLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Ascomycin is a close structural analog of FK506 and is a potent immunosuppressant. It binds to FKBP (FK506-binding protein) and suppresses its proline rotamase activity. The ascomycin-FKBP complex inhibits calcineurin, a type 2B phosphatase.
Off-white solid
Soluble in DMSO, methanol or ethanol
Verpackung: Shipping temperature: Ambient
Formel:
C₄₃H₆₉NO₁₂ Molecular Weight: 790 g/mol Lagertemperatur: Gefrierschrank |
MDL:
MFCD06198665 CAS-Nummer: 104987-12-4 |
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