Gossypol ≥90%

Lieferant: ENZO LIFE SCIENCES

Synonyme: 2,2'-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene), 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde, Thespesin

BMLEI1300100
ENZOBMLEI1300100EA 134 EUR
ENZOBMLEI1300100
Gossypol ≥90%
Gossypol

Male antifertility agent


Mixture of ~65% (+)- and ~35% (-)-enantiomers. Male antifertility agent with antispermatogenic activity. Shows antitumor, antiviral and antioxidant actions. Small molecule inhibitor of Bcl-2/Bcl-XL. Induces apoptosis. Synergizes with radiation and chemotherapy in vitro. Reversible inhibitor of protein phosphatase 2B (PP2B; calcineurin). Protein kinase C (PKC) inhibitor. Inhibits activities of the mitotic kinesin Eg5 (IC50=10.8µM/L). Inhibits RBL-1, 5-lipoxygenase (IC50=0.3µM) and 12-lipoxygenase (IC50=0.7µM). Inhibits PAF and leukotriene-induced guinea pig parenchyma contractions. Novel direct-acting inhibitor of calcineurin.


Isolated from Gossypium genus, Malvaceae.

Formel: C₃₀H₃₀O₈
Molecular Weight: 518,56 g/mol
MDL: MFCD00017352
CAS-Nummer: 303-45-7
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