D-erythro-Sphingosine ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES

Synonyme: D-Sphingosine, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, (2S,3R,E)-2-Amino-4-octadecene-1,3-diol, 4-Sphingenine, (2S,3R,E)-2-Aminooctadec-4-ene-1,3-diol

BMLEI1550100
ENZOBMLEI1550100EA 442 EUR
ENZOBMLEI1550100
D-erythro-Sphingosine ≥98% (durch TLC)
D-erythro-Sphingosine

Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.


  • Potent and selective inhibitor of protein kinase C


White to off-white solid.


Soluble in 100% ethanol (25mg/ml warm) or DMSO (25mg/ml warm).

Formel: C₁₈H₃₇NO₂
Molecular Weight: 299,50 g/mol
Lagertemperatur: Gefrierschrank
MDL: MFCD00036751
CAS-Nummer: 123-78-4
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