17-AAG ≥98% (durch TLC)
Lieferant: ENZO LIFE SCIENCES
HSP90 inhibitor
17-AAG is a less toxic and more stable analog of geldanamycin. It is an HSP90 inhibitor that displays a 100-fold higher affinity for HSP90 derived from tumor cells compared to HSP90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity. Inducer of macroautophagy.
Semisynthetic derivative from geldanamycin.
Formel:
C₃₁H₄₃N₃O₈ |
MDL:
MFCD04973892 CAS-Nummer: 75747-14-7 |
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