17-AAG ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES

BMLEI3080001
ENZOBMLEI3080001EA 279 EUR
ENZOBMLEI3080001
17-AAG ≥98% (durch TLC)
17-AAG

HSP90 inhibitor


17-AAG is a less toxic and more stable analog of geldanamycin. It is an HSP90 inhibitor that displays a 100-fold higher affinity for HSP90 derived from tumor cells compared to HSP90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity. Inducer of macroautophagy.


Semisynthetic derivative from geldanamycin.

Formel: C₃₁H₄₃N₃O₈
MDL: MFCD04973892
CAS-Nummer: 75747-14-7
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=90b9052935688ccf7dc261260023c4e1198965fd&vid=7885fc5cd91276063aed0c291412f52309bf43ac&prid=web&clid=SAPDAM

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