17-AAG ≥98% (durch TLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin, (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
HSP90 inhibitor
17-AAG is a less toxic and more stable analog of geldanamycin. It is an HSP90 inhibitor that displays a 100-fold higher affinity for HSP90 derived from tumor cells compared to HSP90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity. Inducer of macroautophagy.
Semisynthetic derivative from geldanamycin.
Formel:
C₃₁H₄₃N₃O₈ Molecular Weight: 585.7 g/mol |
MDL:
MFCD04973892 CAS-Nummer: 75747-14-7 |
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