DuP-697 ≥98% (durch TLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulphonyl)phenyl)-thiophene
BMLEI3580005
ENZOBMLEI3580005EA
164
EUR
ENZOBMLEI3580005
DuP-697 ≥98% (durch TLC)
DuP-697
DuP-697 is a highly selective and irreversible inhibitor of cyclooxygenase-2 (COX-2). (COX-2 IC50=10 nm, COX-1 IC50=800 nm). It is an orally effective anti-inflammatory, analgesic and antipyretic agent which is not ulcerogenic. Inhibition of COX-2 by DuP-697 and other inhibitors exacerbates ischemia-induced myocardial dysfunction in the rabbit. It inhibits angiogenesis and induces apoptosis in human endothelial cells.
Formel:
C₁₇H₁₂BrFO₂S₂ Molecular Weight: 411,3 g/mol |
CAS-Nummer:
88149-94-4 |
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