Zebularine ≥98% (durch TLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
4-Deoxyuridine, 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Dnmt inhibitor
- Purification: TLC: 30% Methanol/methylene chloride + 1% H2O, Rf = 0.3
Zebularine is a DNA methylation inhibitor which acts by forming a covalent complex with DNMT. It displays antiangiogenic activity and markedly inhibits vessel formation in different tumor models. It reactivates silenced E-cadherin and potentiates the effects of other epigenetic therapeutics such as vorinistat. Induces differentiation of mesenchymal cells into cardiomyocytes. Inhibits cytidine deaminase.
Formel:
C₉H₁₂N₂O₅ Molecular Weight: 228.20 g/mol |
MDL:
MFCD04973699 CAS-Nummer: 3690-10-6 |
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