Chaetocin ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES

Synonyme: (3S,3′S,5aR,5′aR,10bR,10′bR,11aS,11′aS)-2,2′,3,3′,5a,5′a,6,6′-Octahydro-3,3′-bis(hydroxymethyl)-2,2′-dimethyl[10b,10′b(11H,11′H)-bi-3,11a-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole]-1,1′,4,4′-tetrone

BMLGR3490200
ENZOBMLGR3490200EA 114 EUR
ENZOBMLGR3490200
Chaetocin ≥98% (durch TLC)
Chaetocin

Methyltransferase inhibitor


Chaetocin, an antitumor antibiotic, is a thiodioxopiperazine natural product produced by Chaetomium species. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.


Isolated from Chaetomium sp-

Formel: C₃₀H₂₈N₆O₆S₄
Molecular Weight: 696,839 g/mol
MDL: MFCD00133163
CAS-Nummer: 28097-03-2

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