Chaetocin ≥98% (durch TLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
(3S,3′S,5aR,5′aR,10bR,10′bR,11aS,11′aS)-2,2′,3,3′,5a,5′a,6,6′-Octahydro-3,3′-bis(hydroxymethyl)-2,2′-dimethyl[10b,10′b(11H,11′H)-bi-3,11a-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole]-1,1′,4,4′-tetrone
Methyltransferase inhibitor
Chaetocin, an antitumor antibiotic, is a thiodioxopiperazine natural product produced by Chaetomium species. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.
Isolated from Chaetomium sp-
Formel:
C₃₀H₂₈N₆O₆S₄ Molecular Weight: 696,839 g/mol |
MDL:
MFCD00133163 CAS-Nummer: 28097-03-2 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...