Fluor-de-Lys® SIRT2 deacetylase substrate

Lieferant: ENZO LIFE SCIENCES

BMLKI1790005
ENZOBMLKI1790005EA 249 EUR
ENZOBMLKI1790005
Fluor-de-Lys® SIRT2 deacetylase substrate
Proteine und Peptide

Fluor de Lys®-SIRT2 is a fluorogenic peptide substrate for SIRT2 (human Sirtuin 2).


Based on residues 317-320 of p53 (Gln-Pro-Lys-Lys(Ac)), a site of regul atory acetylation by the PCAF acetyltransferase (lysine 320), it was the best for SIRT2 from among a panel of substrates patterned on p53, Histone H3, and Histone H4 acetylation sites.


Fluor de Lys®-SIRT2 is deacetylated by SIRT2 at a rate of more than 50-fold that of the acetylated lysine substrate, Fluor de Lys® (BML-KI104; acetylated substrates both at 25 µM, 500 µM NAD+).


Must be used in conjunction with Fluor de Lys® Developer II (BML-KI176). Sufficient for 100 assays of human recombinant SIRT2 (BML-SE251; 2U/well, 100 µM substrate).

Bestellen


Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Mehr About VWR