IKK-NBD peptide
Lieferant: ENZO LIFE SCIENCES
NF-kappaB inhibitor
The peptide consists of two domains - an antennapedia homeodomain that confers cell permeability and the T735 to E745 region of IKKbeta which is the NEMO binding domain (NBD). It is a selective inhibitor of NFkappaB activation. Blocks interaction of NEMO (an IKB complex regulatory protein) with the IkappaB kinase complex. The peptide (100 µM) inhibits E-selectin expression in human umbilical vein endothelial cells treated with TNFalpha and inhibits LPS-induced nitric acid release from a macrophage cell line In an experimental mouse model of acute inflammation, IKK-NBD peptide (topically applied) inhibited PMA induced ear inflammation. Sold under license from Vanderbilt University
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...