Ansamitocin P-3 ≥93% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-maytansine, Maytansinol isobutyrate, Antibiotic C 15003P3, (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Cchloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl isobutyrate, NSC292222
Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. It shares the same binding site as rhizoxin and phomopsin A on porcine brain tubulin. Maytansine and its analogs cause extensive disassembly of the microtubule and totally prevent tubulin spiralization.
- Microtubule inhibitor
White to off-white crystalline solid.
Soluble in DMSO.
Formel:
C₃₂H₄₃ClN₂O₉ Molecular Weight: 635,14 g/mol Lagertemperatur: Gefrierschrank |
MDL:
MFCD00274586 CAS-Nummer: 66547-09-9 |
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