A camelid single-domain antibody (sdAb, called Nanobody by Ablynx) is a peptide chain about 110 amino acids long comprising one variable domain of a heavy-chain antibody (VHH fragment). Like a whole antibody, a single-domain antibody is able to bind selectively to a specific antigen. Such antibodies allow a broad range of applications in biotechnical as well as therapeutic fields due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and cause anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.
- MonoRab™ technology guarantees high affinity: Kd ~10 to 11 M
- No cross reactivity with other species
- Specific to camelid IgG2 and IgG3
- Recognize conformational epitopes of the VHH domain
- Recognize both camelid and humanized VHHs
GenScript has developed a series of rabbit monoclonal (MonoRab) anti-VHH antibodies to facilitate your research of VHHs. Our anti-VHH antibodies recognize conformational epitopes of the VHH domain of camelid lgG2 and lgG3 subclasses. It is not necessary to add a tag to VHH for detection anymore.
Type:
Antigen: VHH
Clonality: Monoclonal
Clone: 45H8
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: