Human recombinant CD40L multimeric (from CHO cells)

Lieferant: ProSci Inc.

90-289
PRSI90-289EA 620 EUR
PRSI90-289
Human recombinant CD40L multimeric (from CHO cells)
Proteine und Peptide

MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.


Fusion-Tag: DDDDK Tag


This recombinant proteins is for research use only.

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