Human recombinant pyruvate kinase M2 (from E. coli)

Lieferant: ProSci Inc.

92-296
PRSI92-296EA 0 EUR
PRSI92-296
Human recombinant pyruvate kinase M2 (from E. coli)
Enzyme

Pyruvate kinase isoform M2 (PKM2) is a member of the pyruvate kinase (PK) family, a pivotal glycolytic enzyme that is consistently changed during tumorigenesis.


This recombinant protein can be used for biological assays. For research use only.


Fusion-Tag: N-6 His tag


PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets. As the rate-controlling enzyme in glycolysis, PKM2, has also been found to be expressed in embryonic, proliferating, and tumor cells, and it has been considered to be crucial for the metabolism and growth of tumor cells. Recent studies have shown that PKM2 promotes cell proliferation and suppresses cell apoptosis in various tumors. In addition, it has been reported that the PKM2 knockdown affects the Akt and ERK protein kinases.

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