Anti-PAX5 Mouse Monoclonal Antibody [clone: 24]

Lieferant: IMMUNOLOGIC
ILM6108-C01 ILM6108-C05 ILM6108-C1
ILM6108-C01EA 398 EUR
ILM6108-C01 ILM6108-C05 ILM6108-C1
Anti-PAX5 Mouse Monoclonal Antibody [clone: 24]
Antikörper
Paired box (PAX) gene family whose protein products are transcription factors involved in development. The conserved paired box DNA-binding domain is found in the N-terminal region of Pax proteins. An octomer and homeodomain sequence are conserved in the center of the proteins. The Ser/Thr/ Pro-rich region in the C-terminal portion contains a conserved 100 amino acid transactivating domain. Pax-5 influences the expression of several B-cell-specific genes, such as CD 19 and CD 20. It is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Its mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. It has been found to be important in both B cell and nervous system development.

  • Control: Tonsil
  • Dilution Range: 1:100-1:200 for immunohistochemical staining
  • Dilution Range: 1:250 for western blotting

Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH 6,0 for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections.

Type: Primary
Antigen: PAX5
Clonality: Monoclonal
Clone: 24
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
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