Anti-HLA-DRB1 Mouse Monoclonal Antibody (Purified) [clone: LN-3]

Lieferant: Biotium
BNUB0057-500 BNUB0057-100
BNUB0057-500EA 511 EUR
BNUB0057-500 BNUB0057-100
Anti-HLA-DRB1 Mouse Monoclonal Antibody (Purified) [clone: LN-3]
Antikörper
This MAb reacts with a 28 kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

Type: Primary
Antigen: HLA-DRB1
Clonality: Monoclonal
Clone: LN-3
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human, Monkey
Bestellen

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Mehr About VWR