Anti-TGM2 Mouse Monoclonal Antibody (CF405S) [clone: TGM2/419]

Lieferant: Biotium
BNC040419-500 BNC040419-100
BNC040419-500EA 560 EUR
BNC040419-500 BNC040419-100
Anti-TGM2 Mouse Monoclonal Antibody (CF405S) [clone: TGM2/419]
Antikörper
Recognizes a 77-85 kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

Type: Primary
Antigen: TGM2
Clonality: Monoclonal
Clone: TGM2/419
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human, Monkey, Mouse, Rabbit, Rat
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