Dexamethason ≥99% (durch TLC)

Lieferant: ENZO LIFE SCIENCES

Synonyme: 9-Fluor-11β,17α,21-trihydroxy-16α-methyl-pregna-1,4-dien-3,20-dion, Dexamethasonum

BMLEI1260001 BMLEI1260005
ENZOBMLEI1260001EA 89.1 EUR
ENZOBMLEI1260001 ENZOBMLEI1260005
Dexamethason ≥99% (durch TLC)
Dexamethason

Glucocorticoid receptor ligand


Anti-inflammatory glucocorticoid with anti-inflammatory activity. Induces the production of phospholipase A2 inhibitory protein (lipocortin). Inhibits induction of nitric oxide synthase (NOS) (IC50=5nM). Induces apoptosis in eosinophils, but inhibits it in neutrophils. Both effects are blocked by RU-486. Modulates osteogenesis of mesenchymal stem cells. Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Oral dexamethasone administration induces an increase in insulin resistance in humans. Activates Indoleamine 2,3-dioxygenase (IDO) in plasmacytoid dendritic cells in vivo and thus promotes tryptophan catabolism and thereby suppression of T cells.

Formel: C₂₂H₂₉FO₅
Molecular Weight: 392,47 g/mol
MDL: MFCD00064136
CAS-Nummer: 50-02-2
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=2df05c1caf851acea3505319027eadc29a17a510&vid=2908861702a2afaca0b1f9e1e1e89ed845f628b1&prid=web&clid=SAPDAM

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