SMER28 (synthetisch) ≥98% (durch TLC)
Lieferant: ENZO LIFE SCIENCES
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Gefahr
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Synonyme:
N-Allyl-6-bromoquinazolin-4-amine
Small molecule inducer of autophagy important for neurodegenerative disease research.
Chemical inducer of autophagy which acts via an mTOR-independent mechanism. It increased autophagosome synthesis and enhanced the clearance of model autophagy substrates such as A53T alpha-synuclein and mutant huntingtin fragments. It reduced Aβ peptide and AAP-CTF levels in an alzheimers model and attenuated mutant huntingtin-fragment toxicity in Huntington's disease models, suggesting therapeutic potential.
Soluble in DMSO (8 mg/ml) or 100% ethanol (2 mg/ml).
Formel:
C₁₁H₁₀BrN₃ Molecular Weight: 264,126 g/mol Lagertemperatur: Gefrierschrank |
MDL:
MFCD02166825 CAS-Nummer: 307538-42-7 |
Spezifikation Testergebnisse
Source | Synthetic |
Purity (TLC) | ≥98% |
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