Cyclopamine ≥98% (durch TLC)

Lieferant: ENZO LIFE SCIENCES AG

ENZOBMLGR3340005EA 564.3 EUR
ENZOBMLGR3340005 ENZOBMLGR3340001
Cyclopamine ≥98% (durch TLC)
Cyclopamine

Blocks Hedgehog signaling


Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 µM. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells

Formel: C₂₇H₄₁NO₂
Molecular Weight: 411,63 g/mol
MDL: MFCD09878269
CAS-Nummer: 4449-51-8
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