DAPT ≥98% (durch NMR)

Lieferant: ENZO LIFE SCIENCES

Synonyme: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate, (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu, (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester

ALX270416M005 ALX270416M025
ENZOALX270416M005EA 165 EUR
ENZOALX270416M005 ENZOALX270416M025
DAPT ≥98% (durch NMR)
DAPT

gamma-Secretase inhibitor


Cell permeable inhibitor of γ-secretase (IC50=115nM for total β-amyloid, IC50=200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD)Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.

Formel: C₂₃H₂₆F₂N₂O₄
Molecular Weight: 432,47 g/mol
MDL: MFCD04974585
CAS-Nummer: 208255-80-5

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