ABT-888 ≥98% (durch HPLC)
Lieferant: ENZO LIFE SCIENCES
Synonyme:
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide dihydrochloride, Veliparib 2HCl
PARP inhibitor
Potent inhibitor of PARP-1 and PARP-2 (potency ≤5nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radiopotentiation. Is toxic to both oxic and hypoxic cells. Enantiomeric purity ≥97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.
Formel:
C₁₃H₁₈Cl₂N₄O Molecular Weight: 317,214 g/mol |
MDL:
MFCD12407402 CAS-Nummer: 912445-05-7 |
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