ABT-888 ≥98% (durch HPLC)

Lieferant: ENZO LIFE SCIENCES

Synonyme: (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide dihydrochloride, Veliparib 2HCl

ALX270444M001 ALX270444M005 ALX270444M025
ENZOALX270444M001EA 121 EUR
ENZOALX270444M001 ENZOALX270444M005 ENZOALX270444M025
ABT-888 ≥98% (durch HPLC)
ABT-888

PARP inhibitor


Potent inhibitor of PARP-1 and PARP-2 (potency ≤5nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radiopotentiation. Is toxic to both oxic and hypoxic cells. Enantiomeric purity ≥97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.

Formel: C₁₃H₁₈Cl₂N₄O
Molecular Weight: 317,214 g/mol
MDL: MFCD12407402
CAS-Nummer: 912445-05-7

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