Staurosporine ≥98% (durch HPLC)

Lieferant: ENZO LIFE SCIENCES AG

Synonyme: (5S,6R,7R,9R)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one, Antibiotic AM-2282

ALX380014C100 ALX380014C250 ALX380014M001 ALX380014M005
ENZOALX380014C100EA 72.6 EUR
ENZOALX380014C100 ENZOALX380014C250 ENZOALX380014M001 ENZOALX380014M005
Staurosporine ≥98% (durch HPLC)
Staurosporine

Apoptosis inducer.


  • Protein kinase inhibitor
  • Isolated from Streptomyces staurosporeus
  • Off-white to green powder
  • Soluble in ethyl acetate, DMSO (25 mg/ml); dimethyl formamide (25 mg/ml) and slightly soluble in chloroform and methanol
  • Insoluble in water


Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5 nM), CDK2/cyclin A (IC50=7 nM), CDK4/cyclin D (IC50=3-10 µM), CDK5/p25 (IC50=4 nM), GSK-3β (IC50=15 nM), Pim-1 kinase (IC50=10 nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1 µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.

Formel: C₂₈H₂₆N₄O₃
Molecular Weight: 466,541 g/mol
Lagertemperatur: Kühlschrank
MDL: MFCD18252446
CAS-Nummer: 62996-74-1

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