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Image Unavailable-PRSI91-727

Human recombinant Mucin 15 (from cells)

Artikel-Nr: (PRSI91-727)
Lieferant: ProSci Inc.
Beschreibung: Mucin-15 is a single-pass type I membrane protein member of the Mucin family. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoans. A key characteristic of Mucins is their ability to form gels. Therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. Mucin-15 is expressed in many tissues. Mucin-15 is highly glycosylated (N- and O-linked carbohydrates). Mucin-15 may play a role in the cell adhesion to the extracellular matrix.
VE: 1 * 50 µG
Product Image-PRSI31-310

Anti-LCN1 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI31-310)
Lieferant: ProSci Inc.
Beschreibung: LCN1 could play a role in taste reception. LCN1 could be necessary for the concentration and delivery of sapid molecules in the gustatory system. LCN1 can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. LCN1 exhibits an extremely wide ligand pocket.The protein encoded by this gene belongs to the lipocalin family. Lipocalins are a group of extracellular proteins that are able to bind lipophiles by enclosure within their structures to minimize solvent contact. This protein may bind hydrophobic ligands and inhibit cysteine proteinases. It may also play a role in taste reception.
VE: 1 * 50 µG
Image Unavailable-PRSI77-174

Anti-FCER1A Hamster Monoclonal Antibody [clone: FceR1]

Artikel-Nr: (PRSI77-174)
Lieferant: ProSci Inc.
Beschreibung: The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.The MAR-1 antibody is widely used both in flow cytometry and for depletion of cells in vitro/in vivo.
VE: 1 * 0,1 mg

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Image Unavailable-PRSI91-662

Human recombinant Dihydropteridine Reductase (from cells)

Artikel-Nr: (PRSI91-662)
Lieferant: ProSci Inc.
Beschreibung: Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family. QDPR exists as a homodimer. QDPR is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4 and tryptophan hydroxylases. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals in the brain called neurotransmitters, which transmit signals between nerve cells. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C) which is a rare autosomal recessive disorder and is lethal.
VE: 1 * 50 µG
Product Image-PRSI26-840

Anti-EPHX1 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI26-840)
Lieferant: ProSci Inc.
Beschreibung: Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Epoxide hydrolase plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE: 1 * 50 µG
Image Unavailable-PRSI91-011

Human recombinant IL2 (fromE. coli)

Artikel-Nr: (PRSI91-011)
Lieferant: ProSci Inc.
Beschreibung: Recombinant Human Interleukin-2 is a highly purified protein with a molecular weight of approximately 15,300 Daltons. The chemical name is des-alanyl-1, serine-125 Human Interleukin-2. It is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the Human IL-2 gene, and the resulting expression clone encodes a modified Human IL-2. This recombinant form differs from native Interleukin-2 in following ways: 1) it is not glycosylated; 2) the molecule has no N-terminal alanine; 3) the molecule has serine substituted for cysteine at amino acid position 125; 4) the aggregation state of molecule is likely to be different from that of native IL-2.
VE: 1 * 50 µG

Zertifikate


Image Unavailable-PRSI77-175

Anti-FCER1A Hamster Monoclonal Antibody [clone: FceR1]

Artikel-Nr: (PRSI77-175)
Lieferant: ProSci Inc.
Beschreibung: The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.The MAR-1 antibody is widely used both in flow cytometry and for depletion of cells in vitro/in vivo.
VE: 1 * 0,5 mg

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Image Unavailable-PRSI91-244

Human recombinant vinculin (from E. coli)

Artikel-Nr: (PRSI91-244)
Lieferant: ProSci Inc.
Beschreibung: Vinculin is a focal adhesion and cytoskeletal protein that distributed mainly at cell-cell junctions and cell-extracellular matrix (ECM) adhesion that belongs to the Vinculin/ alpha-Catenin family. Vinculin is an Actin-binding protein and component of the Actin-Linking Functional module that senses and feels the mechanical properties of the extracellular environment. Vinculin is also a key factor that couples, transmits, transduces, and regulates mechanical force between the cytoskeleton and adhesion receptors. Vinculin generally forms two structural states, an open (active) and closed (inactive) state, which are controlled by conformational interaction(s) between the head and tail domains. Vinculin is involved in the mechano-chemical signal transmission of cells by binding to a variety of focal adhesion or cytoskeletal proteins, and plays important roles in cell adhesion, extension, motion, proliferation and survival.
VE: 1 * 50 µG
Product Image-PRSI26-034

Anti-ACP2 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI26-034)
Lieferant: ProSci Inc.
Beschreibung: ACP2 is the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.Lysosomal acid phosphatase is comprised of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE: 1 * 50 µG
Product Image-PRSIXPS-2015

Anti-GLRA1 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSIXPS-2015)
Lieferant: ProSci Inc.
Beschreibung: Gamma-amGlycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission. The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Gene targeting in mice showed that gephyrin is required for synaptic clustering of glycine receptors in spinal cord. The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins. These receptors have also been extremely useful in studies of synaptic clustering of receptors. During postnatal motoneuron development, the glycine receptor alpha subunit changes from alpha2 (fetal) to alpha1 (adult).
VE: 1 * 200 µG
Image Unavailable-PRSI33-106

Anti-CDC20 Mouse Monoclonal Antibody [clone: AR12]

Artikel-Nr: (PRSI33-106)
Lieferant: ProSci Inc.
Beschreibung: Cyclins, regulatory subunits which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 kinase (p34Cdc2) exhibits kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested.
VE: 1 * 100 µG

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Image Unavailable-CHATBD2128U.9012

Glycin (H-Gly-OH)

Artikel-Nr: (CHATBD2128U.9012)
Lieferant: CHATTEM CHEMICALS
Beschreibung: Glycin (H-Gly-OH)
VE: 1 * 12 kg

Zertifikate


Image Unavailable-PRSI33-673

Anti-GJB1 Mouse Monoclonal Antibody [clone: M12.13]

Artikel-Nr: (PRSI33-673)
Lieferant: ProSci Inc.
Beschreibung: This Ab recognises a protein of 27-32 kDa, identified as Connexin 32. The connexin family of proteins forms hexameric complexes called connexons that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane alpha-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20-connexin isoforms produces channels with distinct permeability and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another.
VE: 1 * 100 µG

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Product Image-PRSI6955

Anti-TCTEX1D3 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI6955)
Lieferant: ProSci Inc.
Beschreibung: TCTEX1D3 Antibody: Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. TCTEX1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X (SCN10A). TCTEX1D3, also called TCTE3, has been identified as a gene responsible for congenital diaphragmatic hernia (CDH).
VE: 1 * 100 µG
Product Image-PRSI6953

Anti-TCTEX1D2 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI6953)
Lieferant: ProSci Inc.
Beschreibung: TCTEX1D2 Antibody: Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. TCTEX1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X (SCN10A). TCTEX1D2, also called TCTEX1 domain containing 2, belongs to the dynein light chain TCTEX-type family. Its function is still under investigation.
VE: 1 * 100 µG
Product Image-PRSI6957

Anti-TCTEX1D4 Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI6957)
Lieferant: ProSci Inc.
Beschreibung: TCTEX1D4 Antibody: Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. TCTEX1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X (SCN10A). TCTEX1D4, also called TCTEX2 beta, interacts with different members of the TGF-beta receptor family, and when overexpressed, inhibits TGF-beta signaling.
VE: 1 * 100 µG
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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