Anti-SEPT5 Mouse Monoclonal Antibody

Lieferant: ENZO LIFE SCIENCES
ADI905781100
ENZOADI905781100EA 374 EUR
ENZOADI905781100
Anti-SEPT5 Mouse Monoclonal Antibody
Antikörper
Septin 5 (Sept5/CDCrel-1) is a member of the Septin family of cytoskeletal GTPases. Septin 5 expression is primarily associated with synaptic vesicles in cells of the nervous system where it acts to inhibit exocytosis, although it has also been characterized as an inhibitor of aggregation and release of storage granules in platelets. Phosphorylation of Septin 5 at Ser17 by Cdk5-p35 has been shown to mediate the interaction of Septin 5 with the SNARE protein Syntaxin-1A, regulating neurotransmitter release. Targeted disruption of the Septin 5 gene in mice failed to produce an obvious neurological phenotype, indicating its loss may be overcome by functional redundancy of other septins. Septin 5 is one of several Parkin (an E3 ubiquitin ligase) associated substrates whose accumulation results in cellular toxicity related to the onset of autosomal recessive Parkinson Disease.

  • For Western Blot

Recognizes human, mouse and rat Septin 5/Cdcrel-1. Detects a band of ~43kDa by Western blot.

Type: Primary
Antigen: SEPT5
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
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