Anti-Neuropeptide Y Receptor Type 1 Rabbit Polyclonal Antibody

Lieferant: ENZO LIFE SCIENCES
ADI905798100
ENZOADI905798100EA 438 EUR
ENZOADI905798100
Anti-Neuropeptide Y Receptor Type 1 Rabbit Polyclonal Antibody
Antikörper
Neuropeptide Y (NPY) and the closely related peptide YY (PYY) and pancreatic polypeptide (PP) are a family of 36-amino acid, tyrosine-rich peptides with amidated C-terminal ends that are known to regulate gastrointestinal and central nervous system functions including food intake and the inhibition of anxiety. Four functional NPY receptors (Y1/Y2/Y4/Y5) have been identified to date, with a fifth (y6) being a non-functional receptor in primates that is absent from the rat genome. Y1, Y2, and Y5 receptors preferentially bind NPY and PYY, while the Y4 receptor preferentially binds PP. All four receptors signal via coupling to Gi/o alpha subunits, inhibiting adenylyl cyclase activity, thereby decreasing intracellular cAMP levels. Y1 receptor deficient mice display a variety of physical and behavioral phenotypes including obesity, hyperinsulinemia, and increased territorial behavior.

Recognizes human, mouse and rat neuropeptide Y receptor Y1. Predicted MW of ~44kDa. Higher MW species (~80kDa) also observed by Western blot which may reflects post-translational modification or dimerization of the receptor. Predicted species reactivity based on epitope sequence homology: horse, chimpanzee, rhesus macaque, guinea pig.

For ELISA, Flow Cytometry, Western Blot

Bestellinformation: Manufactured by Proteimax.

Type: Primary
Antigen: NEUROPEPTIDE Y RECEPTOR TYPE 1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human
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