Anti-PTGDR2 Rabbit Polyclonal Antibody

Lieferant: ENZO LIFE SCIENCES
ADI905800100
ENZOADI905800100EA 429 EUR
ENZOADI905800100
Anti-PTGDR2 Rabbit Polyclonal Antibody
Antikörper
The conversion of arachidonic acid to prostaglandin H2 (PGH2) by cyclooxygenase (COX) enzymes is the first step in the synthesis of prostanoids. Prostaglandin D2 (PGD2) is synthesized from PGH2 by the action of PGD synthase, and its actions in vasodilation and platelet activation are mediated via activation of two identified G-protein coupled receptors (GPCRs): DP1 and DP2 (formerly CRTH2). Both DP1 and DP2 receptors are coupled to Gs alpha subunits, resulting in increased adenylyl cyclase activity and cAMP production upon agonist binding. DP1 receptor is expressed moderately in the ileum and weakly in the lung, stomach, and uterus of mice, and weakly in the small intestine of humans. In rodents, expression of PGD synthase and the DP1 receptor is seen in the leptomeninges, where it is believed they play a role in the induction of sleep. The DP1 receptor may also oppose DP2-mediated activation of basophils, eosinophils, and Th2 cells.

Recognizes rat PGD2 receptor (DP1). Predicted MW of ~40kDa. Predicted species reactivity based on epitope sequence homology: mouse.

For ELISA, Flow Cytometry, Immunohistochemistry, Western Blot

Bestellinformation: Manufactured by Proteimax.

Type: Primary
Antigen: PTGDR2
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Rat
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