Anti-TOP2A Mouse Monoclonal Antibody [clone: 1C5]

Lieferant: Enzo Life Sciences
ADIKAMCC210E
ENZOADIKAMCC210EEA 469 EUR
ENZOADIKAMCC210E
Anti-TOP2A Mouse Monoclonal Antibody [clone: 1C5]
Antikörper
DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.

Type: Primary
Antigen: TOP2A
Clonality: Monoclonal
Clone: 1C5
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Mouse
Isotype: IgG2a
Reactivity: Human
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