Anti-CIAP1 Rat Monoclonal Antibody

Lieferant: ENZO LIFE SCIENCES
ALX803335C100
ENZOALX803335C100EA 470 EUR
ENZOALX803335C100
Anti-CIAP1 Rat Monoclonal Antibody
Antikörper
All members of the inhibitor of apoptosis proteins (IAP) family contain at least one, but usually three copies of baculovirus IAP repeat (BIR), a ~70-aa zinc binding domain, and upon overexpression suppress apoptosis. The BIR motif is capable of interacting with caspases and occluding their catalytic pockets. Certain IAPs also possess C-terminal RING domains. RING-containing proteins often act as E3 ubiquitin ligases and can catalyse the degradation of both, themselves and selected target proteins through ubiquitylation. So far, eight human IAPs have been identified: Apollon (Bruce), c-IAP1 (HIAP2; MIHB), c-IAP2 (HIAP1; MIHC), ILP-2 (Ts-IAP), Livin (ML-IAP; KIAP), NAIP, Survivin (TIAP) and XIAP (ILP-1; MIHA). c-IAP1 has been shown to inhibit specific caspases.

  • For Western Blot

Recognizes human and mouse c-IAP1. Detects a band of ~62kD by Western blot.

Type: Primary
Antigen: CIAP1
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Rat
Isotype:
Reactivity:
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