Anti-Ryanodine Receptor Mouse Monoclonal Antibody

Lieferant: ENZO LIFE SCIENCES
ALX804015C100
ENZOALX804015C100EA 908 EUR
ENZOALX804015C100
Anti-Ryanodine Receptor Mouse Monoclonal Antibody
Antikörper
The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

  • For Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot

Recognizes human, mouse, rat, dog, rabbit, guinea pig, chicken, amphibian and fish RyR-2. Detects a band of 565kDa by Western blot. In non-mammalian vertebrates, a doublet is seen at 565kDa representing the alpha and beta isoforms of the receptor. Cross-reacts weakly with RyR-1.

Type: Primary
Antigen: RYANODINE RECEPTOR
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
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