Anti-L1CAM Mouse Monoclonal Antibody [clone: UJ127]

Lieferant: ProSci Inc.
33-172
PRSI33-172EA 773 EUR
PRSI33-172
Anti-L1CAM Mouse Monoclonal Antibody [clone: UJ127]
Antikörper
This antibody recognises a cell surface protein of 220-240 kDa, identified as L1CAM (L1 cell adhesion molecule). The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). L1CAM also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. antibody to L1CAM is useful in the identification of primitive neuroectodermal tumors. The antibody binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

Flow Cytometry: 0,5-1 µg/million cells IF: 1 - 2 µg/ml The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

Type: Primary
Antigen: L1CAM
Clonality: Monoclonal
Clone: UJ127
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human
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