Anti-TRPM8 Rabbit Polyclonal Antibody

Lieferant: ProSci Inc.
55-973
PRSI55-973EA 620 EUR
PRSI55-973
Anti-TRPM8 Rabbit Polyclonal Antibody
Antikörper
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

  • For WB starting dilution is: 1:1000
  • For IHC-P starting dilution is: 1:50~100

Type: Primary
Antigen: TRPM8
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: Rabbit Ig
Reactivity: Human
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